Drug interactions
Ethinyl estradiol-drospirenone + Salmeterol
Severity: Minor
Ethinyl estradiol-drospirenone and Salmeterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salmeterol, a beta-agonist, can lower serum potassium by driving it into cells, whereas drospirenone may raise it. The effects oppose each other and no important interaction is established.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Salmeterol belongs to Respiratory.
Why it happens
Opposing effects on serum potassium; no clinically significant interaction mechanism is established.
What to do
No action is needed beyond usual potassium checks in patients using high-dose beta-agonists.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Salmeterol?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salmeterol, a beta-agonist, can lower serum potassium by driving it into cells, whereas drospirenone may raise it. The effects oppose each other and no important interaction is established.
How serious is the interaction between Ethinyl estradiol-drospirenone and Salmeterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond usual potassium checks in patients using high-dose beta-agonists.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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