Drug interactions
Ethinyl estradiol-drospirenone + Somapacitan
Severity: Moderate
Ethinyl estradiol-drospirenone and Somapacitan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral estrogens reduce hepatic production of IGF-1 in response to growth hormone, which can blunt the effect of growth hormone analogs such as somapacitan. Higher doses of the hormone may be needed in women taking oral estrogen.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Somapacitan belongs to Endocrine.
Why it happens
Oral estrogen suppresses hepatic GH signaling, lowering IGF-1 generation (first-pass hepatic effect).
What to do
Monitor IGF-1 and clinical response, and increase the growth hormone dose as needed. A non-oral estrogen route may be considered if suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Somapacitan?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral estrogens reduce hepatic production of IGF-1 in response to growth hormone, which can blunt the effect of growth hormone analogs such as somapacitan. Higher doses of the hormone may be needed in women taking oral estrogen.
How serious is the interaction between Ethinyl estradiol-drospirenone and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor IGF-1 and clinical response, and increase the growth hormone dose as needed. A non-oral estrogen route may be considered if suitable.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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