Drug interactions
Ethinyl estradiol-drospirenone + Tetracycline
Severity: Minor
Ethinyl estradiol-drospirenone and Tetracycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracycline has been thought to lower ethinyl estradiol levels via altered gut flora. Controlled data do not show reduced contraceptive efficacy, so the risk is low.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Tetracycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Tetracycline belongs to Anti Bacterial.
Why it happens
Theoretical reduction of enterohepatic recirculation of ethinyl estradiol via altered gut flora; not confirmed.
What to do
No routine change is required; reinforce consistent pill use and backup contraception if vomiting or diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Tetracycline
- Acitretin + Tetracycline Contraindicated
- Methoxyflurane + Tetracycline Contraindicated
- Isotretinoin + Tetracycline Major
- Palovarotene + Tetracycline Major
- Strontium ranelate + Tetracycline Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Tetracycline?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Tetracycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tetracycline has been thought to lower ethinyl estradiol levels via altered gut flora. Controlled data do not show reduced contraceptive efficacy, so the risk is low.
How serious is the interaction between Ethinyl estradiol-drospirenone and Tetracycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is required; reinforce consistent pill use and backup contraception if vomiting or diarrhea occurs.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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