Drug interactions
Ethinyl estradiol-drospirenone + Timolol
Severity: Minor
Ethinyl estradiol-drospirenone and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has anti-mineralocorticoid activity and can raise serum potassium. Systemic beta-blockade with timolol can modestly impair cellular potassium uptake, so additive hyperkalemia is possible, mainly in patients with renal impairment or other risk factors.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Timolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect: aldosterone antagonism by drospirenone plus reduced beta-2-mediated cellular potassium uptake from beta-blockade.
What to do
Monitor serum potassium in patients with renal impairment, diabetes or other hyperkalemia risks, particularly in the first cycle of combined use. Ophthalmic timolol carries less risk.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethinyl estradiol-drospirenone and Timolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Timolol?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone has anti-mineralocorticoid activity and can raise serum potassium. Systemic beta-blockade with timolol can modestly impair cellular potassium uptake, so additive hyperkalemia is possible, mainly in patients with renal impairment or other risk factors.
How serious is the interaction between Ethinyl estradiol-drospirenone and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients with renal impairment, diabetes or other hyperkalemia risks, particularly in the first cycle of combined use. Ophthalmic timolol carries less risk.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
