Drug interactions
Ethinyl estradiol-drospirenone + Valsartan
Severity: Moderate
Ethinyl estradiol-drospirenone and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan reduces aldosterone effects and potassium excretion, and drospirenone adds anti-mineralocorticoid activity. Together they can increase the risk of hyperkalemia, especially in renal impairment or diabetes.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Valsartan belongs to Cardiovascular.
Why it happens
Additive hyperkalemia from angiotensin receptor blockade and drospirenone aldosterone antagonism.
What to do
Check serum potassium during the first treatment cycle and periodically afterward; consider a different contraceptive in patients with renal impairment or a history of hyperkalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Valsartan?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valsartan reduces aldosterone effects and potassium excretion, and drospirenone adds anti-mineralocorticoid activity. Together they can increase the risk of hyperkalemia, especially in renal impairment or diabetes.
How serious is the interaction between Ethinyl estradiol-drospirenone and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first treatment cycle and periodically afterward; consider a different contraceptive in patients with renal impairment or a history of hyperkalemia.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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