Drug interactions
Ethinyl estradiol-levonorgestrel + Idelalisib
Severity: Moderate
Ethinyl estradiol-levonorgestrel and Idelalisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and may increase exposure to ethinyl estradiol and levonorgestrel. Higher hormone levels could increase estrogen-related effects, including thrombosis risk, in patients already at risk from malignancy.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Idelalisib belongs to Oncology.
Why it happens
Strong inhibition of CYP3A-mediated metabolism of the contraceptive hormones.
What to do
Monitor for estrogenic adverse effects and thrombotic risk, and consider an alternative non-hormonal contraceptive. Reassess the need for estrogen in the setting of active cancer.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethinyl estradiol-levonorgestrel and Idelalisib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Idelalisib?
MediHelp rates the interaction as moderate. Ethinyl estradiol-levonorgestrel and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A inhibitor and may increase exposure to ethinyl estradiol and levonorgestrel. Higher hormone levels could increase estrogen-related effects, including thrombosis risk, in patients already at risk from malignancy.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Idelalisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects and thrombotic risk, and consider an alternative non-hormonal contraceptive. Reassess the need for estrogen in the setting of active cancer.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
