Drug interactions
Ethinyl estradiol-levonorgestrel + Mineral oil
Severity: Minor
Ethinyl estradiol-levonorgestrel and Mineral oil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral mineral oil may reduce absorption of fat-soluble drugs, which could theoretically lower hormone absorption from oral contraceptives. Clinical evidence of contraceptive failure is lacking.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Mineral oil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Mineral oil belongs to Gastrointestinal Tract.
Why it happens
Mineral oil can dissolve lipophilic drugs in the gut and speed intestinal transit, which may reduce absorption.
What to do
Avoid taking mineral oil within a couple of hours of the contraceptive pill, and prefer another laxative for regular use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Mineral oil
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Mineral oil?
MediHelp rates the interaction as minor. Ethinyl estradiol-levonorgestrel and Mineral oil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral mineral oil may reduce absorption of fat-soluble drugs, which could theoretically lower hormone absorption from oral contraceptives. Clinical evidence of contraceptive failure is lacking.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Mineral oil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking mineral oil within a couple of hours of the contraceptive pill, and prefer another laxative for regular use.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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