Drug interactions
Cholecalciferol + Mineral oil
Severity: Minor
Cholecalciferol and Mineral oil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral mineral oil can dissolve fat-soluble vitamins in the gut lumen and carry them out in the stool. Regular use may lower absorption of cholecalciferol and contribute to vitamin D insufficiency.
What this interaction means in plain words
Cholecalciferol and Mineral oil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cholecalciferol belongs to Musculoskeletal; Mineral oil belongs to Gastrointestinal Tract.
Why it happens
Mineral oil is a non-absorbable lipophilic substance that sequesters fat-soluble vitamins and reduces their intestinal absorption.
What to do
Avoid regular long-term mineral oil use in patients who need vitamin D, or separate the doses by several hours. Check 25-hydroxyvitamin D if use is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cholecalciferol
- Cholecalciferol + Digoxin Major
- Aluminum hydroxide + Cholecalciferol Moderate
- Calcium acetate + Cholecalciferol Moderate
- Calcium Carbonate + Cholecalciferol Moderate
- Calcium chloride + Cholecalciferol Moderate
- Calcium citrate + Cholecalciferol Moderate
Other interactions of Mineral oil
Frequently asked questions
Can I take Cholecalciferol with Mineral oil?
MediHelp rates the interaction as minor. Cholecalciferol and Mineral oil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral mineral oil can dissolve fat-soluble vitamins in the gut lumen and carry them out in the stool. Regular use may lower absorption of cholecalciferol and contribute to vitamin D insufficiency.
How serious is the interaction between Cholecalciferol and Mineral oil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular long-term mineral oil use in patients who need vitamin D, or separate the doses by several hours. Check 25-hydroxyvitamin D if use is prolonged.
What other medicines interact with Cholecalciferol?
MediHelp also lists interactions of Cholecalciferol with, for example, Digoxin, Aluminum hydroxide, Calcium acetate. The full list is on the Cholecalciferol page.
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