Drug interactions
Desogestrel-ethinyl estradiol + Mineral oil
Severity: Minor
Desogestrel-ethinyl estradiol and Mineral oil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral mineral oil may dissolve lipophilic drugs in the gut and reduce their absorption, which could lower contraceptive hormone exposure. Clinical evidence is lacking.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Mineral oil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel-ethinyl estradiol belongs to Endocrine; Mineral oil belongs to Gastrointestinal Tract.
Why it happens
Mineral oil sequesters lipophilic steroids in the intestinal lumen and reduces absorption.
What to do
Separate administration by at least two hours and avoid regular use of mineral oil laxatives with the pill.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Mineral oil
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Mineral oil?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Mineral oil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral mineral oil may dissolve lipophilic drugs in the gut and reduce their absorption, which could lower contraceptive hormone exposure. Clinical evidence is lacking.
How serious is the interaction between Desogestrel-ethinyl estradiol and Mineral oil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate administration by at least two hours and avoid regular use of mineral oil laxatives with the pill.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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