Drug interactions
Ethinyl estradiol-levonorgestrel + Paromomycin
Severity: Minor
Ethinyl estradiol-levonorgestrel and Paromomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral paromomycin is minimally absorbed but could theoretically alter gut flora and estrogen recycling. Clinical evidence of contraceptive failure is lacking.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Paromomycin belongs to Anti Bacterial.
Why it happens
Theoretical reduction in enterohepatic recirculation of ethinyl estradiol via gut flora alteration.
What to do
No change is routinely needed; advise backup contraception if gastrointestinal illness impairs absorption.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Paromomycin?
MediHelp rates the interaction as minor. Ethinyl estradiol-levonorgestrel and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral paromomycin is minimally absorbed but could theoretically alter gut flora and estrogen recycling. Clinical evidence of contraceptive failure is lacking.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Paromomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is routinely needed; advise backup contraception if gastrointestinal illness impairs absorption.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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