Drug interactions
Ethinyl estradiol-levonorgestrel + Pretomanid
Severity: Moderate
Ethinyl estradiol-levonorgestrel and Pretomanid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid-containing regimens are associated with liver injury. Combined hormonal contraceptives are metabolized by the liver and have hepatic effects, but no clear pharmacokinetic or toxic interaction between these two agents is well established.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Pretomanid belongs to Anti Bacterial.
Why it happens
No established mechanism; concern is additive hepatotoxic potential, which is largely theoretical.
What to do
Monitor liver function tests regularly during pretomanid therapy and stop hepatotoxic agents if transaminases rise. Review the contraceptive choice if liver injury develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Pretomanid?
MediHelp rates the interaction as moderate. Ethinyl estradiol-levonorgestrel and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pretomanid-containing regimens are associated with liver injury. Combined hormonal contraceptives are metabolized by the liver and have hepatic effects, but no clear pharmacokinetic or toxic interaction between these two agents is well established.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Pretomanid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests regularly during pretomanid therapy and stop hepatotoxic agents if transaminases rise. Review the contraceptive choice if liver injury develops.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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