Drug interactions
Ethinyl estradiol-levonorgestrel + Ranolazine
Severity: Minor
Ethinyl estradiol-levonorgestrel and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol is a weak CYP3A inhibitor and may modestly raise ranolazine levels. Higher ranolazine exposure can contribute to dose-related QT prolongation, dizziness and nausea.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Ranolazine belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4 by ethinyl estradiol reduces ranolazine metabolism.
What to do
No dose change is usually needed; monitor for dizziness, nausea or QT-related symptoms when starting or stopping the contraceptive.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Ranolazine?
MediHelp rates the interaction as minor. Ethinyl estradiol-levonorgestrel and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinyl estradiol is a weak CYP3A inhibitor and may modestly raise ranolazine levels. Higher ranolazine exposure can contribute to dose-related QT prolongation, dizziness and nausea.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for dizziness, nausea or QT-related symptoms when starting or stopping the contraceptive.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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