Drug interactions
Ethinyl estradiol-levonorgestrel + Repotrectinib
Severity: Major
Ethinyl estradiol-levonorgestrel and Repotrectinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib is a CYP3A4 inducer and can lower exposure to both the estrogen and the progestin in hormonal contraceptives. This may cause contraceptive failure, which matters because repotrectinib can harm a fetus.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Repotrectinib belongs to Oncology.
Why it happens
CYP3A4 induction by repotrectinib increases the metabolism of ethinyl estradiol and levonorgestrel.
What to do
Use an effective non-hormonal contraceptive method during repotrectinib therapy and for the period recommended in its labeling after the last dose. Do not rely on hormonal contraceptives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Repotrectinib?
MediHelp rates the interaction as major. Ethinyl estradiol-levonorgestrel and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Repotrectinib is a CYP3A4 inducer and can lower exposure to both the estrogen and the progestin in hormonal contraceptives. This may cause contraceptive failure, which matters because repotrectinib can harm a fetus.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Repotrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an effective non-hormonal contraceptive method during repotrectinib therapy and for the period recommended in its labeling after the last dose. Do not rely on hormonal contraceptives.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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