Drug interactions
Ethinyl estradiol-levonorgestrel + Rucaparib
Severity: Minor
Ethinyl estradiol-levonorgestrel and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak CYP3A4 inhibitor and may modestly raise exposure to ethinyl estradiol and levonorgestrel. The clinical effect is likely small.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Rucaparib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4 by rucaparib reduces hormone metabolism.
What to do
Monitor for increased estrogen or progestin adverse effects. Note that rucaparib carries embryo-fetal toxicity, so reliable contraception remains necessary.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Rucaparib?
MediHelp rates the interaction as minor. Ethinyl estradiol-levonorgestrel and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak CYP3A4 inhibitor and may modestly raise exposure to ethinyl estradiol and levonorgestrel. The clinical effect is likely small.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased estrogen or progestin adverse effects. Note that rucaparib carries embryo-fetal toxicity, so reliable contraception remains necessary.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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