Drug interactions
Ethinyl estradiol-levonorgestrel + Stiripentol
Severity: Moderate
Ethinyl estradiol-levonorgestrel and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has both inhibitory and inducing effects on CYP3A4, so exposure to ethinyl estradiol and levonorgestrel may change unpredictably. Contraceptive efficacy could be reduced.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed inhibition and induction of CYP3A4 and other enzymes by stiripentol alters hormone metabolism.
What to do
Advise an additional non-hormonal contraceptive method during stiripentol treatment. Monitor for breakthrough bleeding or hormone-related adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Stiripentol?
MediHelp rates the interaction as moderate. Ethinyl estradiol-levonorgestrel and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol has both inhibitory and inducing effects on CYP3A4, so exposure to ethinyl estradiol and levonorgestrel may change unpredictably. Contraceptive efficacy could be reduced.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal contraceptive method during stiripentol treatment. Monitor for breakthrough bleeding or hormone-related adverse effects.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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