Drug interactions
Ethinyl estradiol-norgestimate + Fedratinib
Severity: Moderate
Ethinyl estradiol-norgestimate and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may raise exposure to CYP3A4 substrates such as ethinyl estradiol and norgestimate. This may increase estrogen- and progestin-related adverse effects.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-norgestimate belongs to Endocrine; Fedratinib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP3A4, reducing the metabolic clearance of ethinyl estradiol.
What to do
Monitor for estrogenic adverse effects such as hypertension, nausea and thrombotic symptoms. Consider an alternative contraceptive method if tolerability is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Fedratinib?
MediHelp rates the interaction as moderate. Ethinyl estradiol-norgestimate and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and may raise exposure to CYP3A4 substrates such as ethinyl estradiol and norgestimate. This may increase estrogen- and progestin-related adverse effects.
How serious is the interaction between Ethinyl estradiol-norgestimate and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects such as hypertension, nausea and thrombotic symptoms. Consider an alternative contraceptive method if tolerability is poor.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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