Drug interactions
Ethinyl estradiol-norgestimate + Fluconazole
Severity: Minor
Ethinyl estradiol-norgestimate and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can modestly increase ethinyl estradiol exposure, particularly with repeated or higher doses. Contraceptive efficacy is not reduced, and the main concern is estrogen-related side effects.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-norgestimate belongs to Endocrine; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP3A4 and reduces ethinyl estradiol metabolism.
What to do
No dose change is generally required; monitor for estrogenic adverse effects such as nausea, breast tenderness or headache during prolonged fluconazole use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Fluconazole?
MediHelp rates the interaction as minor. Ethinyl estradiol-norgestimate and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole can modestly increase ethinyl estradiol exposure, particularly with repeated or higher doses. Contraceptive efficacy is not reduced, and the main concern is estrogen-related side effects.
How serious is the interaction between Ethinyl estradiol-norgestimate and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required; monitor for estrogenic adverse effects such as nausea, breast tenderness or headache during prolonged fluconazole use.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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