Drug interactions
Ethinyl estradiol-norgestimate + Hemin
Severity: Moderate
Ethinyl estradiol-norgestimate and Hemin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens and some progestins can induce hepatic delta-aminolevulinic acid synthase and may precipitate porphyria attacks. This opposes the therapeutic effect of hemin in acute porphyria.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Hemin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-norgestimate belongs to Endocrine; Hemin belongs to Miscellaneous.
Why it happens
Hormonal induction of hepatic ALA synthase increases porphyrin precursors, counteracting hemin's feedback suppression.
What to do
Avoid hormonal contraceptives in patients with acute porphyria where possible. If used, monitor for porphyria symptoms and porphyrin precursors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Hemin
- Hemin + Secobarbital Major
- Argatroban + Hemin Moderate
- Bazedoxifene-conjugated estrogens + Hemin Moderate
- Dabigatran etexilate + Hemin Moderate
- Dalteparin + Hemin Moderate
- Desogestrel-ethinyl estradiol + Hemin Moderate
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Hemin?
MediHelp rates the interaction as moderate. Ethinyl estradiol-norgestimate and Hemin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estrogens and some progestins can induce hepatic delta-aminolevulinic acid synthase and may precipitate porphyria attacks. This opposes the therapeutic effect of hemin in acute porphyria.
How serious is the interaction between Ethinyl estradiol-norgestimate and Hemin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid hormonal contraceptives in patients with acute porphyria where possible. If used, monitor for porphyria symptoms and porphyrin precursors.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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