Drug interactions
Ethinyl estradiol-norgestimate + Levoketoconazole
Severity: Moderate
Ethinyl estradiol-norgestimate and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and may substantially raise ethinyl estradiol and progestin concentrations. This can increase estrogenic adverse effects including thromboembolic risk.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-norgestimate belongs to Endocrine; Levoketoconazole belongs to Endocrine.
Why it happens
Levoketoconazole strongly inhibits CYP3A4, reducing the metabolic clearance of ethinyl estradiol and norgestimate.
What to do
Monitor blood pressure and for estrogenic adverse effects, and consider a lower-estrogen or non-hormonal contraceptive. Review the need for estrogen in patients with thrombotic risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Levoketoconazole?
MediHelp rates the interaction as moderate. Ethinyl estradiol-norgestimate and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and may substantially raise ethinyl estradiol and progestin concentrations. This can increase estrogenic adverse effects including thromboembolic risk.
How serious is the interaction between Ethinyl estradiol-norgestimate and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for estrogenic adverse effects, and consider a lower-estrogen or non-hormonal contraceptive. Review the need for estrogen in patients with thrombotic risk factors.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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