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Drug interactions

Ethinyl estradiol-norgestimate + Lixisenatide

Severity: Minor

Ethinyl estradiol-norgestimate and Lixisenatide: minor interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Lixisenatide slows gastric emptying and may lower or delay absorption of oral contraceptives. This could reduce contraceptive effectiveness if the dose is poorly timed.

What this interaction means in plain words

Ethinyl estradiol-norgestimate and Lixisenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.

Ethinyl estradiol-norgestimate belongs to Endocrine; Lixisenatide belongs to Endocrine.

Evidence level: Moderate

Why it happens

Delayed gastric emptying by lixisenatide slows and may reduce absorption of oral ethinyl estradiol.

What to do

Take the oral contraceptive at least 1 hour before lixisenatide or at least 11 hours after it.

What to ask your pharmacist

  • Is there anything I should notice while taking both?
  • Do I need to tell my doctor at the next visit?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Ethinyl estradiol-norgestimate with Lixisenatide?

MediHelp rates the interaction as minor. Ethinyl estradiol-norgestimate and Lixisenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lixisenatide slows gastric emptying and may lower or delay absorption of oral contraceptives. This could reduce contraceptive effectiveness if the dose is poorly timed.

How serious is the interaction between Ethinyl estradiol-norgestimate and Lixisenatide?

MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take the oral contraceptive at least 1 hour before lixisenatide or at least 11 hours after it.

What other medicines interact with Ethinyl estradiol-norgestimate?

MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.

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