Drug interactions
Ethinyl estradiol-norgestimate + Mineral oil
Severity: Minor
Ethinyl estradiol-norgestimate and Mineral oil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral mineral oil may dissolve fat-soluble substances in the gut and reduce absorption of lipophilic steroid hormones. In theory this could lower contraceptive hormone exposure, though clinical significance is uncertain with occasional use.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Mineral oil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-norgestimate belongs to Endocrine; Mineral oil belongs to Gastrointestinal Tract.
Why it happens
Mineral oil acts as a lipid solvent in the intestinal lumen, which may reduce absorption of lipophilic drugs.
What to do
Avoid regular use of mineral oil and take the contraceptive at least 2 hours before or after any dose. Counsel the patient to use backup contraception if prolonged diarrhea or heavy laxative use occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Mineral oil
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Mineral oil?
MediHelp rates the interaction as minor. Ethinyl estradiol-norgestimate and Mineral oil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral mineral oil may dissolve fat-soluble substances in the gut and reduce absorption of lipophilic steroid hormones. In theory this could lower contraceptive hormone exposure, though clinical significance is uncertain with occasional use.
How serious is the interaction between Ethinyl estradiol-norgestimate and Mineral oil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use of mineral oil and take the contraceptive at least 2 hours before or after any dose. Counsel the patient to use backup contraception if prolonged diarrhea or heavy laxative use occurs.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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