Drug interactions
Ethinyl estradiol-norgestimate + Trazodone
Severity: Minor
Ethinyl estradiol-norgestimate and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogen-containing contraceptives might slightly increase trazodone exposure, potentially increasing sedation or orthostatic hypotension. The legacy comparison with tricyclics is not applicable, since trazodone is not a tricyclic, and the evidence is weak.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-norgestimate belongs to Endocrine; Trazodone belongs to Central Nervous System.
Why it happens
Possible modest inhibition of CYP-mediated trazodone metabolism by ethinyl estradiol; not well established.
What to do
No empirical dose change is needed. Monitor for excess sedation or dizziness and adjust the trazodone dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Trazodone?
MediHelp rates the interaction as minor. Ethinyl estradiol-norgestimate and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogen-containing contraceptives might slightly increase trazodone exposure, potentially increasing sedation or orthostatic hypotension. The legacy comparison with tricyclics is not applicable, since trazodone is not a tricyclic, and the evidence is weak.
How serious is the interaction between Ethinyl estradiol-norgestimate and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for excess sedation or dizziness and adjust the trazodone dose if they occur.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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