Drug interactions
Ethinyl estradiol-norgestimate + Trimipramine
Severity: Minor
Ethinyl estradiol-norgestimate and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral contraceptive estrogens may raise trimipramine concentrations, potentially increasing sedation, anticholinergic effects and orthostatic hypotension. Data are limited and the effect is variable.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-norgestimate belongs to Endocrine; Trimipramine belongs to Central Nervous System.
Why it happens
Ethinyl estradiol may inhibit oxidative metabolism of tricyclics, although this is not firmly established.
What to do
Monitor for tricyclic adverse effects when starting or stopping the contraceptive. Reduce the trimipramine dose if toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Trimipramine?
MediHelp rates the interaction as minor. Ethinyl estradiol-norgestimate and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral contraceptive estrogens may raise trimipramine concentrations, potentially increasing sedation, anticholinergic effects and orthostatic hypotension. Data are limited and the effect is variable.
How serious is the interaction between Ethinyl estradiol-norgestimate and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects when starting or stopping the contraceptive. Reduce the trimipramine dose if toxicity appears.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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