Drug interactions
Ethosuximide + Levoketoconazole
Severity: Moderate
Ethosuximide and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and can substantially reduce clearance of CYP3A4-metabolised drugs such as ethosuximide. Ethosuximide accumulation may cause drowsiness, ataxia, nausea and other toxicity.
What this interaction means in plain words
Ethosuximide and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethosuximide belongs to Central Nervous System; Levoketoconazole belongs to Endocrine.
Why it happens
Strong inhibition of CYP3A4 by levoketoconazole decreasing ethosuximide metabolism.
What to do
Monitor for ethosuximide toxicity and consider checking serum levels, with ethosuximide dose reduction as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Ethosuximide with Levoketoconazole?
MediHelp rates the interaction as moderate. Ethosuximide and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and can substantially reduce clearance of CYP3A4-metabolised drugs such as ethosuximide. Ethosuximide accumulation may cause drowsiness, ataxia, nausea and other toxicity.
How serious is the interaction between Ethosuximide and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ethosuximide toxicity and consider checking serum levels, with ethosuximide dose reduction as needed.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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