Drug interactions
Ethosuximide + Omaveloxolone
Severity: Minor
Ethosuximide and Omaveloxolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone may induce CYP3A4 and lower exposure to sensitive substrates. Ethosuximide concentrations could decrease, potentially reducing seizure control.
What this interaction means in plain words
Ethosuximide and Omaveloxolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethosuximide belongs to Central Nervous System; Omaveloxolone belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by omaveloxolone increasing ethosuximide clearance.
What to do
Monitor seizure control and ethosuximide levels when starting omaveloxolone, adjusting the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Ethosuximide with Omaveloxolone?
MediHelp rates the interaction as minor. Ethosuximide and Omaveloxolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omaveloxolone may induce CYP3A4 and lower exposure to sensitive substrates. Ethosuximide concentrations could decrease, potentially reducing seizure control.
How serious is the interaction between Ethosuximide and Omaveloxolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and ethosuximide levels when starting omaveloxolone, adjusting the dose if needed.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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