Drug interactions
Ethosuximide + Palbociclib
Severity: Minor
Ethosuximide and Palbociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib is a weak-to-moderate time-dependent CYP3A4 inhibitor and ethosuximide is partly metabolized by CYP3A4. Ethosuximide levels could rise, increasing nausea, drowsiness and dizziness.
What this interaction means in plain words
Ethosuximide and Palbociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethosuximide belongs to Central Nervous System; Palbociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated ethosuximide metabolism by palbociclib.
What to do
Monitor for ethosuximide adverse effects such as sedation and GI upset. Consider checking ethosuximide levels or reducing the dose if toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Other interactions of Palbociclib
Frequently asked questions
Can I take Ethosuximide with Palbociclib?
MediHelp rates the interaction as minor. Ethosuximide and Palbociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Palbociclib is a weak-to-moderate time-dependent CYP3A4 inhibitor and ethosuximide is partly metabolized by CYP3A4. Ethosuximide levels could rise, increasing nausea, drowsiness and dizziness.
How serious is the interaction between Ethosuximide and Palbociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ethosuximide adverse effects such as sedation and GI upset. Consider checking ethosuximide levels or reducing the dose if toxicity appears.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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