Drug interactions
Ethosuximide + Repotrectinib
Severity: Moderate
Ethosuximide and Repotrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib induces CYP3A4 and may reduce ethosuximide exposure. This may lead to loss of seizure control.
What this interaction means in plain words
Ethosuximide and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethosuximide belongs to Central Nervous System; Repotrectinib belongs to Oncology.
Why it happens
Repotrectinib induces CYP3A4, increasing ethosuximide metabolism.
What to do
Monitor seizure control and ethosuximide serum levels. Increase the ethosuximide dose if breakthrough seizures occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Ethosuximide with Repotrectinib?
MediHelp rates the interaction as moderate. Ethosuximide and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repotrectinib induces CYP3A4 and may reduce ethosuximide exposure. This may lead to loss of seizure control.
How serious is the interaction between Ethosuximide and Repotrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and ethosuximide serum levels. Increase the ethosuximide dose if breakthrough seizures occur.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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