Drug interactions
Ethosuximide + Rucaparib
Severity: Minor
Ethosuximide and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate CYP3A inhibitor in vitro and may raise exposure of CYP3A substrates. Ethosuximide levels could increase, with possible drowsiness, nausea and ataxia.
What this interaction means in plain words
Ethosuximide and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethosuximide belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Rucaparib may inhibit CYP3A4, reducing ethosuximide metabolism.
What to do
Monitor for ethosuximide adverse effects and consider checking levels if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Ethosuximide with Rucaparib?
MediHelp rates the interaction as minor. Ethosuximide and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a moderate CYP3A inhibitor in vitro and may raise exposure of CYP3A substrates. Ethosuximide levels could increase, with possible drowsiness, nausea and ataxia.
How serious is the interaction between Ethosuximide and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ethosuximide adverse effects and consider checking levels if symptoms occur.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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