Drug interactions
Ethotoin + Fluconazole
Severity: Moderate
Ethotoin and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP2C9 and CYP2C19, which contribute to hydantoin metabolism, so ethotoin levels may rise. This could cause dizziness, ataxia, nystagmus and sedation; the effect is extrapolated from phenytoin, which has a well-documented interaction.
What this interaction means in plain words
Ethotoin and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probable inhibition of CYP2C9/2C19 metabolism of ethotoin by fluconazole, extrapolated from phenytoin.
What to do
Monitor for signs of hydantoin toxicity such as ataxia and nystagmus and for seizure control. Reduce the ethotoin dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Ethotoin with Fluconazole?
MediHelp rates the interaction as moderate. Ethotoin and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits CYP2C9 and CYP2C19, which contribute to hydantoin metabolism, so ethotoin levels may rise. This could cause dizziness, ataxia, nystagmus and sedation; the effect is extrapolated from phenytoin, which has a well-documented interaction.
How serious is the interaction between Ethotoin and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of hydantoin toxicity such as ataxia and nystagmus and for seizure control. Reduce the ethotoin dose if toxicity develops.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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