Drug interactions
Etodolac + Fluoxetine
Severity: Moderate
Etodolac and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an SSRI with an NSAID substantially increases the risk of upper gastrointestinal bleeding compared with either drug alone. The risk is greatest in older patients and those with prior ulcer disease or on anticoagulants.
What this interaction means in plain words
Etodolac and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Fluoxetine belongs to Central Nervous System.
Why it happens
SSRIs deplete platelet serotonin and impair platelet aggregation while NSAIDs inhibit platelet function and damage gastric mucosa, giving additive bleeding risk.
What to do
Avoid the combination in patients at high bleeding risk, otherwise add a proton pump inhibitor for gastroprotection. Counsel patients to report black stools or hematemesis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Etodolac with Fluoxetine?
MediHelp rates the interaction as moderate. Etodolac and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an SSRI with an NSAID substantially increases the risk of upper gastrointestinal bleeding compared with either drug alone. The risk is greatest in older patients and those with prior ulcer disease or on anticoagulants.
How serious is the interaction between Etodolac and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients at high bleeding risk, otherwise add a proton pump inhibitor for gastroprotection. Counsel patients to report black stools or hematemesis.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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