Drug interactions
Etodolac + Imatinib
Severity: Moderate
Etodolac and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib can cause thrombocytopenia and myelosuppression, and etodolac impairs platelet function and irritates the gastric mucosa. The combination increases the risk of bleeding, particularly gastrointestinal.
What this interaction means in plain words
Etodolac and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Imatinib belongs to Oncology.
Why it happens
Additive effects on hemostasis: imatinib-related reduction in platelet count and NSAID platelet inhibition and mucosal injury.
What to do
Monitor blood counts regularly and watch for bleeding, and avoid the NSAID when platelet counts are low. Prefer paracetamol for analgesia where suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Etodolac with Imatinib?
MediHelp rates the interaction as moderate. Etodolac and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib can cause thrombocytopenia and myelosuppression, and etodolac impairs platelet function and irritates the gastric mucosa. The combination increases the risk of bleeding, particularly gastrointestinal.
How serious is the interaction between Etodolac and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts regularly and watch for bleeding, and avoid the NSAID when platelet counts are low. Prefer paracetamol for analgesia where suitable.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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