Drug interactions
Etodolac + Levofloxacin
Severity: Moderate
Etodolac and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levofloxacin can lower the seizure threshold, and concurrent NSAID use may add to this risk. Seizures are uncommon but more likely in patients with epilepsy, renal impairment or elevated doses.
What this interaction means in plain words
Etodolac and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Levofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolone antagonism of GABA-A receptor binding, possibly potentiated by NSAIDs.
What to do
Avoid the combination in patients with seizure history or CNS disease, and adjust levofloxacin dose for renal function. Stop levofloxacin if neurological excitation or seizures develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Etodolac with Levofloxacin?
MediHelp rates the interaction as moderate. Etodolac and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levofloxacin can lower the seizure threshold, and concurrent NSAID use may add to this risk. Seizures are uncommon but more likely in patients with epilepsy, renal impairment or elevated doses.
How serious is the interaction between Etodolac and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with seizure history or CNS disease, and adjust levofloxacin dose for renal function. Stop levofloxacin if neurological excitation or seizures develop.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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