Drug interactions
Etodolac + Milnacipran
Severity: Moderate
Etodolac and Milnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Milnacipran, a serotonin-norepinephrine reuptake inhibitor, impairs platelet function and combined with an NSAID raises the risk of bleeding, notably in the upper gastrointestinal tract. The risk is higher in older patients and those with a history of ulcers.
What this interaction means in plain words
Etodolac and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Milnacipran belongs to Central Nervous System.
Why it happens
Reduced platelet serotonin uptake combined with NSAID platelet inhibition and mucosal injury produces additive bleeding risk.
What to do
Monitor for signs of GI bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients. Use the lowest effective NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Etodolac with Milnacipran?
MediHelp rates the interaction as moderate. Etodolac and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Milnacipran, a serotonin-norepinephrine reuptake inhibitor, impairs platelet function and combined with an NSAID raises the risk of bleeding, notably in the upper gastrointestinal tract. The risk is higher in older patients and those with a history of ulcers.
How serious is the interaction between Etodolac and Milnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients. Use the lowest effective NSAID dose for the shortest duration.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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