Drug interactions
Etodolac + Nadolol
Severity: Moderate
Etodolac and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular NSAID use can weaken the antihypertensive effect of nadolol. Blood pressure may rise gradually over days to weeks.
What this interaction means in plain words
Etodolac and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Nadolol belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal and vascular prostaglandins causes sodium and water retention and vasoconstriction.
What to do
Check blood pressure regularly during concurrent therapy and adjust the antihypertensive dose as needed. Limit NSAID duration or use paracetamol when appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Nadolol
Frequently asked questions
Can I take Etodolac with Nadolol?
MediHelp rates the interaction as moderate. Etodolac and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regular NSAID use can weaken the antihypertensive effect of nadolol. Blood pressure may rise gradually over days to weeks.
How serious is the interaction between Etodolac and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure regularly during concurrent therapy and adjust the antihypertensive dose as needed. Limit NSAID duration or use paracetamol when appropriate.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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