Drug interactions
Etodolac + Pralatrexate
Severity: Moderate
Etodolac and Pralatrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can delay the renal elimination of pralatrexate, raising its exposure and the risk of toxicities such as mucositis and myelosuppression. The effect is most relevant in patients with reduced kidney function.
What this interaction means in plain words
Etodolac and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Pralatrexate belongs to Oncology.
Why it happens
NSAID reduction of renal blood flow and competition for tubular secretion decreases pralatrexate clearance.
What to do
Monitor for mucositis, blood counts and renal function, and consider dose modification of pralatrexate. Avoid the NSAID where possible, especially with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Pralatrexate
Frequently asked questions
Can I take Etodolac with Pralatrexate?
MediHelp rates the interaction as moderate. Etodolac and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can delay the renal elimination of pralatrexate, raising its exposure and the risk of toxicities such as mucositis and myelosuppression. The effect is most relevant in patients with reduced kidney function.
How serious is the interaction between Etodolac and Pralatrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mucositis, blood counts and renal function, and consider dose modification of pralatrexate. Avoid the NSAID where possible, especially with renal impairment.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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