Drug interactions
Etodolac + Prasugrel
Severity: Major
Etodolac and Prasugrel: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with the potent antiplatelet prasugrel increases the risk of bleeding, especially gastrointestinal bleeding. The risk rises with prolonged NSAID use.
What this interaction means in plain words
Etodolac and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etodolac belongs to Musculoskeletal; Prasugrel belongs to Cardiovascular.
Why it happens
Prasugrel irreversibly blocks platelet P2Y12 receptors while etodolac inhibits platelet COX-1 and damages the gastric mucosa, giving additive effects on hemostasis.
What to do
Avoid routine NSAID use in patients taking prasugrel; prefer paracetamol for pain. If an NSAID is unavoidable, use the shortest course, consider gastroprotection with a proton pump inhibitor, and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Etodolac and Prasugrel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
- Etopan XL 600 mg Film-coated prolonged release tablets - SmPC sections 4.3/4.5 (class statement: Anti-platelet agents; "Anti-platelet agents and selective serotonin reuptake inhibitors (SSRIs): Increased risk of gastrointestinal bleeding (see section 4.4).") — electronic medicines compendium (UK SmPC)
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Prasugrel
Frequently asked questions
Can I take Etodolac with Prasugrel?
MediHelp rates the interaction as major. Etodolac and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an NSAID with the potent antiplatelet prasugrel increases the risk of bleeding, especially gastrointestinal bleeding. The risk rises with prolonged NSAID use.
How serious is the interaction between Etodolac and Prasugrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine NSAID use in patients taking prasugrel; prefer paracetamol for pain. If an NSAID is unavoidable, use the shortest course, consider gastroprotection with a proton pump inhibitor, and monitor for bleeding.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
