Drug interactions
Etodolac + Probenecid
Severity: Moderate
Etodolac and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces the renal clearance of many NSAIDs, which can raise etodolac concentrations and increase the risk of adverse effects such as GI and renal toxicity. Etodolac may also compete with probenecid for tubular secretion, though the clinical effect on probenecid is small.
What this interaction means in plain words
Etodolac and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
Why it happens
Competition for renal organic anion transporter secretion reduces NSAID elimination and prolongs exposure.
What to do
Monitor for NSAID adverse effects and consider a lower etodolac dose. Check renal function in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Etodolac with Probenecid?
MediHelp rates the interaction as moderate. Etodolac and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid reduces the renal clearance of many NSAIDs, which can raise etodolac concentrations and increase the risk of adverse effects such as GI and renal toxicity. Etodolac may also compete with probenecid for tubular secretion, though the clinical effect on probenecid is small.
How serious is the interaction between Etodolac and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for NSAID adverse effects and consider a lower etodolac dose. Check renal function in at-risk patients.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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