Drug interactions
Etodolac + Sertraline
Severity: Moderate
Etodolac and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline combined with an NSAID increases the risk of gastrointestinal and other bleeding beyond either drug alone. Risk is higher in older adults and those with prior ulcers.
What this interaction means in plain words
Etodolac and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Sertraline belongs to Central Nervous System.
Why it happens
SSRI-induced platelet serotonin depletion adds to NSAID platelet inhibition and gastric mucosal injury.
What to do
Consider a proton pump inhibitor in at-risk patients and monitor for signs of bleeding. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Etodolac with Sertraline?
MediHelp rates the interaction as moderate. Etodolac and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline combined with an NSAID increases the risk of gastrointestinal and other bleeding beyond either drug alone. Risk is higher in older adults and those with prior ulcers.
How serious is the interaction between Etodolac and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a proton pump inhibitor in at-risk patients and monitor for signs of bleeding. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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