Drug interactions
Etodolac + Ticagrelor
Severity: Major
Etodolac and Ticagrelor: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs combined with ticagrelor increase the risk of bleeding, especially gastrointestinal bleeding. Both impair platelet function and NSAIDs also injure the gastric mucosa.
What this interaction means in plain words
Etodolac and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etodolac belongs to Musculoskeletal; Ticagrelor belongs to Cardiovascular.
Why it happens
Additive antiplatelet effects (P2Y12 blockade plus COX inhibition) and NSAID-induced mucosal damage.
What to do
Avoid regular NSAIDs in patients on ticagrelor and use paracetamol where possible. If an NSAID is required, add a proton pump inhibitor and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Etodolac with Ticagrelor?
MediHelp rates the interaction as major. Etodolac and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs combined with ticagrelor increase the risk of bleeding, especially gastrointestinal bleeding. Both impair platelet function and NSAIDs also injure the gastric mucosa.
How serious is the interaction between Etodolac and Ticagrelor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAIDs in patients on ticagrelor and use paracetamol where possible. If an NSAID is required, add a proton pump inhibitor and monitor for bleeding.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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