Drug interactions
Etodolac + Voclosporin
Severity: Major
Etodolac and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both voclosporin and NSAIDs can reduce renal blood flow and glomerular filtration. Combining them raises the risk of acute kidney injury and may blunt the renal benefit of voclosporin in lupus nephritis.
What this interaction means in plain words
Etodolac and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etodolac belongs to Musculoskeletal; Voclosporin belongs to Miscellaneous.
Why it happens
Additive renal vasoconstriction from calcineurin inhibition and NSAID prostaglandin inhibition.
What to do
Avoid regular NSAID use where possible. If given, monitor eGFR and serum creatinine closely and stop the NSAID if renal function declines.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Etodolac with Voclosporin?
MediHelp rates the interaction as major. Etodolac and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both voclosporin and NSAIDs can reduce renal blood flow and glomerular filtration. Combining them raises the risk of acute kidney injury and may blunt the renal benefit of voclosporin in lupus nephritis.
How serious is the interaction between Etodolac and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible. If given, monitor eGFR and serum creatinine closely and stop the NSAID if renal function declines.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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