Drug interactions
Etodolac + Warfarin
Severity: Major
Etodolac and Warfarin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etodolac inhibits platelet function and can cause gastrointestinal ulceration, which raises bleeding risk in patients taking warfarin. The INR may not change much but bleeding risk is still higher.
What this interaction means in plain words
Etodolac and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etodolac belongs to Musculoskeletal; Warfarin belongs to Cardiovascular.
Why it happens
Pharmacodynamic synergy of NSAID antiplatelet effects and mucosal injury with vitamin K antagonism, with possible protein-binding displacement.
What to do
Avoid if possible and use paracetamol instead. If the NSAID is necessary, give the shortest course with gastroprotection and monitor INR and for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Etodolac with Warfarin?
MediHelp rates the interaction as major. Etodolac and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etodolac inhibits platelet function and can cause gastrointestinal ulceration, which raises bleeding risk in patients taking warfarin. The INR may not change much but bleeding risk is still higher.
How serious is the interaction between Etodolac and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use paracetamol instead. If the NSAID is necessary, give the shortest course with gastroprotection and monitor INR and for bleeding.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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