Drug interactions
Etomidate + Isocarboxazid
Severity: Moderate
Etomidate and Isocarboxazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may potentiate the effects of anesthetic agents and cause hemodynamic instability during induction. A clear, documented interaction with etomidate specifically is limited.
What this interaction means in plain words
Etomidate and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etomidate belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
Why it happens
Additive CNS depression and hemodynamic effects; the exact mechanism with etomidate is not firmly established.
What to do
Inform the anesthesia team of MAO inhibitor use and monitor blood pressure and heart rate closely during induction, with doses titrated to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Etomidate with Isocarboxazid?
MediHelp rates the interaction as moderate. Etomidate and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors may potentiate the effects of anesthetic agents and cause hemodynamic instability during induction. A clear, documented interaction with etomidate specifically is limited.
How serious is the interaction between Etomidate and Isocarboxazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of MAO inhibitor use and monitor blood pressure and heart rate closely during induction, with doses titrated to effect.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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