Drug interactions
Etomidate + Lorazepam
Severity: Moderate
Etomidate and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is a GABAergic hypnotic anesthetic, and prior or concurrent lorazepam enhances its sedative and respiratory depressant effects. This may increase the depth and duration of sedation and cause hypoventilation.
What this interaction means in plain words
Etomidate and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etomidate belongs to Central Nervous System; Lorazepam belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor potentiation by both agents.
What to do
Use only where airway management and monitoring are available, and reduce the etomidate dose according to response in patients who have received lorazepam.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Etomidate with Lorazepam?
MediHelp rates the interaction as moderate. Etomidate and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etomidate is a GABAergic hypnotic anesthetic, and prior or concurrent lorazepam enhances its sedative and respiratory depressant effects. This may increase the depth and duration of sedation and cause hypoventilation.
How serious is the interaction between Etomidate and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only where airway management and monitoring are available, and reduce the etomidate dose according to response in patients who have received lorazepam.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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