Drug interactions
Etomidate + Morphine
Severity: Moderate
Etomidate and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is an intravenous anesthetic induction agent, and opioids such as morphine add to its sedative and respiratory depressant effects. Hypotension and apnea may be more likely, though this is expected in monitored anesthetic settings.
What this interaction means in plain words
Etomidate and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etomidate belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression via GABA-A potentiation by etomidate and opioid receptor agonism.
What to do
Use only where airway and ventilation can be supported, and titrate doses with monitoring of respiration and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Etomidate with Morphine?
MediHelp rates the interaction as moderate. Etomidate and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etomidate is an intravenous anesthetic induction agent, and opioids such as morphine add to its sedative and respiratory depressant effects. Hypotension and apnea may be more likely, though this is expected in monitored anesthetic settings.
How serious is the interaction between Etomidate and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only where airway and ventilation can be supported, and titrate doses with monitoring of respiration and blood pressure.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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