Drug interactions
Etomidate + Phenelzine
Severity: Moderate
Etomidate and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may potentiate the effects of anesthetic agents, causing deeper or more prolonged CNS depression and hemodynamic variability. Specific data with etomidate are limited and the concern is largely extrapolated.
What this interaction means in plain words
Etomidate and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etomidate belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Why it happens
Additive CNS depression and altered autonomic responsiveness with MAO inhibition.
What to do
Inform the anesthesia team of MAO inhibitor use before induction. Titrate etomidate carefully and monitor blood pressure and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Etomidate with Phenelzine?
MediHelp rates the interaction as moderate. Etomidate and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors may potentiate the effects of anesthetic agents, causing deeper or more prolonged CNS depression and hemodynamic variability. Specific data with etomidate are limited and the concern is largely extrapolated.
How serious is the interaction between Etomidate and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of MAO inhibitor use before induction. Titrate etomidate carefully and monitor blood pressure and heart rate.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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