Drug interactions
Etonogestrel + Ketoconazole
Severity: Minor
Etonogestrel and Ketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole can increase etonogestrel exposure, which could raise progestogenic adverse effects such as irregular bleeding. Contraceptive efficacy is not expected to decrease.
What this interaction means in plain words
Etonogestrel and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etonogestrel belongs to Endocrine; Ketoconazole belongs to Anti Fungals.
Why it happens
Ketoconazole inhibits CYP3A4, reducing etonogestrel metabolism.
What to do
No dose adjustment is usually required; advise patients to report bothersome side effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Etonogestrel
Frequently asked questions
Can I take Etonogestrel with Ketoconazole?
MediHelp rates the interaction as minor. Etonogestrel and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole can increase etonogestrel exposure, which could raise progestogenic adverse effects such as irregular bleeding. Contraceptive efficacy is not expected to decrease.
How serious is the interaction between Etonogestrel and Ketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; advise patients to report bothersome side effects.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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