Drug interactions
Etonogestrel + Metformin-repaglinide
Severity: Minor
Etonogestrel and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins can modestly impair glucose tolerance and may slightly reduce the effectiveness of antidiabetic therapy. With the low systemic dose of etonogestrel implants or rings the clinical effect is usually small.
What this interaction means in plain words
Etonogestrel and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etonogestrel belongs to Endocrine; Metformin-repaglinide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through reduced insulin sensitivity.
What to do
Monitor glucose control after starting etonogestrel; no routine dose change is needed unless control deteriorates.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Etonogestrel
Frequently asked questions
Can I take Etonogestrel with Metformin-repaglinide?
MediHelp rates the interaction as minor. Etonogestrel and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins can modestly impair glucose tolerance and may slightly reduce the effectiveness of antidiabetic therapy. With the low systemic dose of etonogestrel implants or rings the clinical effect is usually small.
How serious is the interaction between Etonogestrel and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose control after starting etonogestrel; no routine dose change is needed unless control deteriorates.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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