Drug interactions
Etonogestrel + Miconazole
Severity: Minor
Etonogestrel and Miconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etonogestrel is metabolized by CYP3A4, and inhibitors can raise progestin levels. Vaginal miconazole produces little systemic exposure, so the effect is expected to be small. Contraceptive efficacy is not reduced.
What this interaction means in plain words
Etonogestrel and Miconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etonogestrel belongs to Endocrine; Miconazole belongs to Anti Fungals.
Why it happens
Miconazole inhibits CYP3A4, slightly reducing etonogestrel clearance.
What to do
No change in contraceptive use is needed. Counsel the patient to report progestogenic adverse effects such as irregular bleeding or mood change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Miconazole
Other interactions of Etonogestrel
Frequently asked questions
Can I take Etonogestrel with Miconazole?
MediHelp rates the interaction as minor. Etonogestrel and Miconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etonogestrel is metabolized by CYP3A4, and inhibitors can raise progestin levels. Vaginal miconazole produces little systemic exposure, so the effect is expected to be small. Contraceptive efficacy is not reduced.
How serious is the interaction between Etonogestrel and Miconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change in contraceptive use is needed. Counsel the patient to report progestogenic adverse effects such as irregular bleeding or mood change.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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