Drug interactions
Etonogestrel + Nifedipine
Severity: Minor
Etonogestrel and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine is not a significant CYP3A4 inhibitor, so a relevant rise in etonogestrel levels is unlikely. No clinically important effect on contraceptive efficacy or safety is expected.
What this interaction means in plain words
Etonogestrel and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etonogestrel belongs to Endocrine; Nifedipine belongs to Cardiovascular.
Why it happens
Theoretical weak CYP3A4 inhibition by nifedipine; no established clinical mechanism.
What to do
No action is required beyond routine monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Etonogestrel
Frequently asked questions
Can I take Etonogestrel with Nifedipine?
MediHelp rates the interaction as minor. Etonogestrel and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine is not a significant CYP3A4 inhibitor, so a relevant rise in etonogestrel levels is unlikely. No clinically important effect on contraceptive efficacy or safety is expected.
How serious is the interaction between Etonogestrel and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is required beyond routine monitoring.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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