Drug interactions
Etonogestrel + Nilotinib
Severity: Minor
Etonogestrel and Nilotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is a weak to moderate CYP3A4 inhibitor and may modestly raise etonogestrel concentrations. A clinically important effect is unlikely, though nilotinib itself requires effective contraception.
What this interaction means in plain words
Etonogestrel and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etonogestrel belongs to Endocrine; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibits CYP3A4, which may reduce etonogestrel metabolism.
What to do
No dose adjustment is needed. Monitor for increased progestogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etonogestrel
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Etonogestrel with Nilotinib?
MediHelp rates the interaction as minor. Etonogestrel and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib is a weak to moderate CYP3A4 inhibitor and may modestly raise etonogestrel concentrations. A clinically important effect is unlikely, though nilotinib itself requires effective contraception.
How serious is the interaction between Etonogestrel and Nilotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for increased progestogenic adverse effects.
What other medicines interact with Etonogestrel?
MediHelp also lists interactions of Etonogestrel with, for example, Amobarbital, Armodafinil, Bosentan. The full list is on the Etonogestrel page.
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